Figure 5.

TRAIL expression by cells of the immune system is required for the development of Con-A–induced hepatitis. TRAIL^+/+ or TRAIL^–/– liver MNCs (2 × 10⁷ cells per mouse) and splenocytes (3 × 10⁷ cells per mouse) were transferred into TRAIL^–/– mice intrahepatically and intrasplenically, respectively. One hour later, mice were injected with Con-A (25 mg/kg of body weight), and serum activities of ALT were assessed 12 hours after the challenge. Data presented are means and SEM of each group (n = 5). Results shown are from one representative experiment of two. The differences between the two groups are statistically significant as determined by ANOVA (P < 0.01).