TABLE 3.
Selected P. aeruginosa phages and prophage-like elements
| Element | Size (kb)a | Features | Reference(s) |
|---|---|---|---|
| LES prophage 2 | 42 | Contains regions of homology to Siphoviridae family phage F10; contributes to virulence in a rat lung chronic infection model | 118, 232 |
| LES prophage 3 | 43 | Contains regions of homology to phage F10, P. aeruginosa strain 2192, and LES prophage 5; contributes to virulence in a rat lung chronic infection model | 232 |
| LES prophage 4 | 37 | Similar in sequence to transposable phage D3122 | 224, 232 |
| LES prophage 5 | 50 | Shares regions of similarity with phage D3; contributes to virulence in a rat lung chronic infection model | 112, 232 |
| LES prophage 6 | 8 | Similar to filamentous phage Pf1 | 92, 232 |
| φCTX | 36 | Double-stranded DNA Myoviridae family phage encoding a pore-forming cytotoxin that contributes to the virulence of P. aeruginosa strains harboring it | 12, 153 |
| PAGI-6 | 44 | Exhibits a high level of sequence identity to φCTX; however, lacks genes encoding φCTX integrase and cytotoxin | 15 |
| D3 | 56 | Double-stranded DNA Siphoviridae family phage containing a “seroconverting operon” that changes lysogenized P. aeruginosa strains from serotype O5 to O16 | 112, 155 |
| Pf1 | 7 | Single-stranded DNA filamentous phage highly upregulated during P. aeruginosa biofilm development | 92, 228 |
| Pf4 | 12 | Single-stranded DNA filamentous phage affecting P. aeruginosa biofilm phenotypic variation and differentiation as well as virulence | 187, 226 |
| PT-6 | NK | Double-stranded DNA Podoviridae family bacteriophage that produces an alginase | 75 |
| R-type and F-type pyocins | 12-15 | Defective prophages related to phage P2 and phage lambda; encode phage tail particles with antibacterial activity; affect susceptibility to fluoroquinolone antibiotics | 19, 25, 154 |
| F116 | 65 | Double-stranded DNA Podoviridae family generalized transducing phage; digests alginate and encodes several putative proteins with amino acid sequence similarity to proteins from fluorescent Pseudomonas species | 32, 118 |
| D3112 | 38 | Double-stranded DNA Siphoviridae family generalized transducing phage with transposase-mediated integration; representative of one of two groups of P. aeruginosa transposable phages (D3112-like and B3-like); like other tailed P. aeruginosa phages, it exemplifies a mosaic genetic structure; predicted to encode several proteins with sequence similarity to other phage proteins as well as proteins from the bacterial plant pathogen Xanthomonas fastidiosa | 224 |
a
NK, not known.