TABLE 4.
Selected P. aeruginosa transposons
| Transposon | Size (kb) | Type | Features | NCBI GenBank accession no. | Reference(s) |
|---|---|---|---|---|---|
| Tn6061 | 26.6 | Complex | Tn3 family transposon; contains 10 antibiotic resistance genes against β-lactamases (blaVEB-1, blaOXA-10), aminoglycosides [ant(2′)-Ia, ant(3″)-Ia, ant(4′)-IIb], tetracycline [tet(G)], rifampin (aar-2), chloramphenicol (cmlA5, floR), and sulfonamides (sul1) | GQ388247 | 46 |
| Tn1213 | 4.1 | Composite | Flanked by ISPa12/ISPa13 insertion sequences; contains β-lactamase blaPER-1 gene expressed under the control of a promoter within insertion sequence ISPa12;associated with P. aeruginosa outbreak in Warsaw, Poland | AY779042 | 60, 174 |
| Tn4401b | 10.0 | Complex | Tn3 family transposon; contains carbapenemase blaKPC-2 gene and two insertion sequences, ISKpn7 and ISKpn6; similar sequence is found in all KPC-expressing Enterobacteriaceae | EU176013 | 150 |
| Tn6001 | 14.6 | Complex | Contains integron In450 carrying metallo-β-lactamase gene blaVIM-3, three copies of aminoglycoside acetyltransferase gene aacA4, aminoglycoside adenylyltransferase gene aadB, sulfonamide resistance gene sul1, orf2 (putative fosfomycin resistance gene), and two other ORFs of unknown function; associated with broad-spectrum antibiotic resistance among P. aeruginosa isolates in Taiwan | EF138817 | 216 |
| Tn801 | 1.5 | Complex | Tn3 family transposon; contains extended-spectrum β-lactamase gene blaTEM-21 preceded by resolvase gene interrupted by insertion sequence IS6100 containing transposase tnpA; associated with ESBL-expressing P. aeruginosa outbreak in nursing home in France | AF080442, AF466526 | 27, 57, 58 |