TABLE 1.
Mean levels of plasma HIV RNA, CD4, CD8, and serum β2-microglobulin in HIV-positive pregnant women by treatment group and in HIV-negative pregnant women at the third trimester, delivery, and postpartum period
| Factor measured and treatment groupa | Mean level (± SE) |
||
|---|---|---|---|
| Third trimester | Delivery | Postpartum | |
| HIV RNA (copies/ml) | |||
| Group I* | 7,248 (±1,529) | 37,970 (±11,027) | 51,517 (±7,396) |
| Group II* | 8,399 (±2,802) | 4,539 (±2,026) | 16,854 (±5,020) |
| Group III* | 42,004 (±10,512) | 15,519 (±3,103) | 34,742 (±6,692) |
| Group IV* | 5,740 (±2,089) | 1,321 (±392) | 3,901 (±1,258) |
| CD4 (cells/ml) | |||
| Group I | 622 (±60) | 729 (±47) | 744 (±44) |
| Group II | 692 (±68) | 759 (±80) | 900 (±82) |
| Group III | 333 (±27) | 360 (±31) | 426 (±32) |
| Group IV | 444 (±34) | 500 (±36) | 565 (±45) |
| HIV-negative* | 1,011 (±63) | 985 (±92) | 1,081 (±62) |
| CD8 (cells/ml) | |||
| Group I* | 799 (±52) | 919 (±79) | 1,057 (±81) |
| Group II* | 850 (±71) | 998 (±144) | 1,218 (±147) |
| Group III* | 809 (±55) | 880 (±68) | 1,038 (±71) |
| Group IV* | 904 (±67) | 906 (±68) | 1,013 (±70) |
| HIV-negative* | 667 (±47) | 719 (±53) | 718 (±44) |
| β2-Microglobulin (mg/liter) | |||
| Group I* | 1.68 (±0.16) | 2.26 (±0.27) | 2.36 (±0.23) |
| Group II* | 1.39 (±0.07) | 1.56 (±0.10) | 1.73 (±0.11) |
| Group III* | 1.78 (±0.08) | 1.81 (±0.09) | 2.33 (±0.10) |
| Group IV* | 1.58 (±0.09) | 1.79 (±0.07) | 1.74 (±0.07) |
| HIV-negative* | 1.15 (±0.05) | 1.39 (±0.10) | 1.38 (±0.04) |
a
Group I, untreated with ARV; group II, ZDV prenatal only; group III, ZDV prenatal and postpartum; group IV, HAART prenatal and postpartum. *, P < 0.05 for time trend.