TABLE 1.
Survival and serum antibody titers of mice vaccinated with a single dose of rKS1/RVFV and challenged with RVFVa
| Route of vaccination | Dose (TCID50) | No. of surviving mice/no. of challenged mice (%) | Prevaccination RVFV IFA titer | RVFV IFA titer (SN titer)b at 21 days postvaccination |
|---|---|---|---|---|
| Intraperitoneal | 104.5 | 2/10 (20) | <16 | 64 (4) |
| Intramuscular | 104.5 | 0/10 | <16 | 64 (4) |
| Subcutaneous | 104.5 | 0/10 | <16 | 64 (<4) |
| Intraperitoneal | 107.25 | 7/10 (70) | <16 | 64 (4) |
| Intramuscular | 107.25 | 6/10 (60) | <16 | 32 (4) |
| Subcutaneous | 107.25 | 2/10 (20) | <16 | 32 (8) |
a
Mice were challenged subcutaneously with 100 LD50 of RVFV at 21 days postvaccination.
b
SN titers to RVFV are in parentheses. The SN titer was not determined with prevaccination sera. IFA (indirect fluorescence antibody) and SN titers are the reciprocal of the last positive dilution determined with pooled sera from each group of mice.