Table 2.
ECTV recombinants expressing IL-4 in resistant C57BL/6 mice replicate to higher titers in spleens and livers than in ECTV-WT infections.
| Virus1 | Days p.i. | Virus infectivity (PFU/ml) | |
|---|---|---|---|
| Spleen | Liver | ||
| -WT | 3 | 1.1×103 ×÷ 2.8 | 1.0×103 ×÷ 0.4 |
| 4 | 2.3×103 ×÷ 1.9 | 3.5×103 ×÷ 0.3 | |
| 5 | 2.7×103 ×÷ 2.0 | 4.3×103 ×÷ 0.06 | |
| 6 | 3.5×102 ×÷ 8.3 | 3.8×102 ×÷ 11.3 | |
| 7 | 7.6×102 ×÷ 0.2 | 1.3×103 ×÷ 0.9 | |
| -7.5E/L-IL-4 | 3 | 7.1×102 ×÷ 2.2 | 2.2×103 ×÷ 0.9 |
| 4 | 4.2×103 ×÷ 0.2 | 4.2×104 ×÷ 0.08 | |
| 5 | 1.4×105 ×÷ 1.9 | 3.7×105 ×÷ 0.2 | |
| 6 | 4.1×106 ×÷ 0.07 | 4.5×106 ×÷ 0.03 | |
| 7 | 4.2×106 ×÷ 0.03 | 4.4×106 ×÷ 0.002 | |
1
Groups of 4 C57BL/6 mice were infected in the left FP route with 1×103 PFU of indicated viruses. At specific time points 4 mice from each infection were bled and sacrificed. Tissues were collected for measurement of virus infectivity and histopathology.