Table 3.

Tissues from ECTV-7.5E/L-IL-4 infected C57BL/6 mice have extensive tissue necrosis without lymphopoiesis.

Description1	-WT	-7.5E/L-IL-4
Focal necrosis in liver	++2	++++3
Monocytes:
-hepatic vessel	±	+++
-bone marrow	±	+++
Splenic necrosis:
-lymphopoiesis	+++	+
-hemorrhage	−	++
-red pulp histocytosis	++	++++
Thymic necrosis	±	++
Popliteal lymph node necrosis	++++	++++
Cervical lymph node lymphopoiesis	+++	−

¹Four mice were infected with ECTV-WT or ECTV-7.5E/L-IL-4 and were sacrificed at 7 days p.i. as described in Table 2. Tissue sections were prepared as described in the Methods and one wax section from each mouse was examined by light microscopy. Only reproducible histological changes are reported (see Methods for complete list of tissues examined).

²Infiltrated with lymphocytes.

³Not infiltrated with lymphocytes.