Table 3.

Stability of etravirine in rat plasma

Storage condition	Nominal concentration	Mean (± SD) percent of nominal concentration remaining (n=3)
4°C temperature for 12 hours
	2.5 ng/mL in rat plasma	99.7 ± 0.39
	50 ng/mL in rat plasma	99.8 ± 4.9
Room temperature in the autosampler for 12 hours
	A reconstituted solution from a 2.5 ng/mL QC sample extraction	99.3 ± 0.11
	A reconstituted solution from a 50 ng/mL QC sample extraction	100.6 ± 6.5
−80°C temperature stored for 30 days
	2.5 ng/mL in rat plasma	99.1 ± 2.3
	50 ng/mL in rat plasma	106 ± 1.3
Freeze-thaw
Cycle 1	2.5 ng/mL in rat plasma	105.0 ± 0.04
	50 ng/mL in rat plasma	102.3 ± 5.4
Cycle 2	2.5 ng/mL in rat plasma	107.9 ± 0.04
	50 ng/mL in rat plasma	98.3 ± 2.8
Cycle 3	2.5 ng/mL in rat plasma	110.6 ± 0.01
	50 ng/mL in rat plasma	113.0 ± 0.44