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Increased expression of MHC class II in the pancreata of pS2-dnRII mice. MHC class II expression was not observed in acinar cells of the pancreas (a) of wild-type FVB/N mice, but increased immunohistochemical intensity of MHC class II molecules was observed in pancreatic acinar cells (b) of pS2-dnRII mice. After the induction of pancreatitis through cerulein injection, MHC class II antigen expression was more markedly increased in transgenic mice (d) than in wild-type littermates (c).
