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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Gastroenterology. 2010 Sep 25;140(1):265–274. doi: 10.1053/j.gastro.2010.09.041

Figure 6. Neutralizing IFN-γ attenuates colitis in KSR1−/−Il10−/− mice.

Figure 6

3-week old KSR1−/−Il10−/− mice were administered 100 µg/mouse neutralizing antibodies against αIgG, αIFN-γ, or αIL-17A intraperitoneally twice per week for a period of 3 weeks and assessed for colitis. A) Mouse colons were removed, flushed, weighed, and measured from the cecum to anus. Solid bars represent the mean length/weight ratio. Error bars are the SEM. B) Colon sections were scored as before for inflammation and injury. Solid bars represent the mean and error bars represent the SEM. C) Representative H&E stained colon sections from KSR1−/−Il10−/− mice administered αIgG, αIFN-γ, or αIL-17A neutralizing antibody. * P < 0.05, ** P < 0.01