Table 2. AR CAG and GGC and PSA (G/A) frequency distribution and association with AR (A1675T) mutation in African Americans and Caucasian Americans with familial prostate cancers.

Characteristics	African American	Caucasians
No. of high-risk families	15	15
No. of PCa-affected males1	37	30
PSA allele frequency2
A	0.484	0.548
G	0.516	0.452
AR (A1675T) allele frequency3
A	0.958	N/A
T	0.042	N/A
PSA genotype linkage4 with:
AR (A1675T) mutation status	1.0	N/A
CAG repeats (≤ 22)	0.857	1.0
GGC repeats (≤ 16)	1.0	1.0
AR mutation linkage5 with:
CAG repeats (≤ 22)	1.0	N/A
GGC repeats (≤ 16)	0.20	N/A

Abbreviations: PCa, prostate cancer; AR, androgen receptor; PSA, prostate-specific antigen; N/A, not applicable.

¹PCa-affected males are brothers within a nuclear family

²Estimated with Mendel v9.0, autosomal

³Estimated with Mendel v9.0, X-linked

⁴Exact P-value using Reconstruction-combination transmission disequilibrium test procedure assuming full sibships

⁵Exact P-values using X-linked reconstruction combination-transmission/disequilibrium Test procedure assuming full sibships.