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. Author manuscript; available in PMC: 2010 Dec 22.
Published in final edited form as: J Infect Dis. 2010 Jul 1;202(1):65–74. doi: 10.1086/653080

Fig. 4. Combinations of clemizole with either interferon, ribavirin, a nucleoside analog or a non-nucleoside analog polymerase inhibitors are not synergistic but additive.

Fig. 4

MacSynergy analysis of the antiviral effect of clemizole in combination with interferon alpha (A), ribavirin (B), NM283 (C) and HCV796 (D) as measured by luciferase reporter-linked replication assays after 72hr of treatment. Differential surface plots at the 95% confidence level are shown. Peaks above the theoretical additive plane indicate synergy, whereas depressions below it indicate antagonism. The colors indicate the level of synergy/antagonism.