Table 1.
Baseline Characteristics of Patients According to Systolic Blood Pressure While Taking Medication
| No. (%) of Patients, Systolic Blood Pressure Control |
P Value | ||||
|---|---|---|---|---|---|
| Tight (n = 2255) | Usual (n = 1970) | Uncontrolled (n = 2175) | |||
| Age, mean (SD), y | 65 (9) | 66 (9) | 67 (9) | <.001 | |
| >70 y | 641 (28) | 629 (32) | 784 (36) | <.001 | |
| BMI, mean (SD) | 30 (6.0) | 31 (6.0) | 31 (6.0) | <.001 | |
| Blood pressure, mean (SD), mm Hg | |||||
| Systolic | 144 (19) | 149 (17) | 159 (19) | <.001 | |
| Diastolic | 85 (12) | 85 (12) | 86 (12) | <.001 | |
| Heart rate, mean (SD), beats/min | 77 (10) | 77 (9) | 77 (10) | .38 | |
| β-Blocker strategy | 1129 (50) | 996 (49) | 1136 (52) | .11 | |
| Women | 1116 (49) | 1065 (54) | 1274 (59) | <.001 | |
| Race/ethnicity | |||||
| White | 896 (40) | 902 (46) | 996 (46) |  |
<.001 |
| Black | 210 (9.3) | 299 (15) | 490 (23) | ||
| Hispanic | 1086 (48) | 733 (37) | 612 (28) | ||
| Other/multiracial | 63 (2.8) | 36 (2.0) | 77 (3.5) | ||
| Prior MI | 797 (35) | 645 (33) | 735 (34) | .19 | |
| Prior stroke/TIA | 184 (8.2) | 168 (8.5) | 236 (11) | .004 | |
| LVH | 596 (26) | 437 (22) | 522 (24) | .004 | |
| Heart failure (New York Heart Association class I–III) | 199 (8.8) | 134 (6.8) | 188 (8.6) | .03 | |
| PAD | 424 (19) | 326 (17) | 366 (17) | .10 | |
| Smoking history | 1080 (48) | 883 (45) | 957 (44) | .02 | |
| Renal impairmenta | 79 (3.5) | 47 (2.4) | 108 (5.0) | <.001 | |
| Hypercholesterolemiab | 1413 (63) | 1221 (62) | 1318 (61) | .34 | |
| Cancer | 81 (3.6) | 60 (3.1) | 74 (3.4) | .61 | |
| Medication use | |||||
| Lipid lowering | 989 (44) | 846 (43) | 856 (39) | .006 | |
| Aspirin or other antiplatelet | 1386 (61) | 1150 (58) | 1264 (58) | .04 | |
| NSAID | 442 (20) | 398 (20) | 414 (19) | .64 | |
| Use of any antihypertensives | 2052 (91) | 1786 (91) | 1957 (90) | .50 | |
Abbreviations: BMI, body mass index, calculated as weight in kilograms divided by height in meters squared; LVH, left ventricular hypertrophy; MI, myocardial infarction; NSAID, nonsteroidal anti-inflammatory drug; PAD, peripheral arterial disease; TIA, transient ischemic attack.
a
History of, or currently elevated serum creatinine level but less than 4 mg/dL (to convert from mg/dL to μmol/L, multiply by 88.4).
b
History of, or currently taking lipid-lowering medications.