Table 2.
Primary and Secondary Outcomes
| Outcome | Systolic Blood Pressure Control | P Valuea | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Tight (n = 2255) | Usual (n = 1970) | Uncontrolled (n = 2175) | |||||||||||
| No. of Events | % (95% CI) | Total Years of Follow- up | Event Rate Per 100 Patient- Years | No. of Events | % (95% CI) | Total Years of Follow- up | Event Rate Per 100 Patient- Years | No. of Events | % (95% CI) | Total Years of Follow- up | Event Rate Per 100 Patient- Years | ||
| Primary outcomeb | 286 | 12.7 (11.3–14.1) | 5741 | 4.98 | 249 | 12.6 (11.2–14.1) | 5339 | 4.66 | 431 | 19.8 (18.1–21.5) | 5775 | 7.46 | <.001 |
| All-cause mortality | 248 | 11.0 (9.7–12.3) | 5811 | 4.27 | 201 | 10.2 (8.9–11.5) | 5423 | 3.71 | 334 | 15.4 (13.8–16.9) | 5975 | 5.59 | <.001 |
| Nonfatal MI | 29 | 1.3 (0.8–1.8) | 5782 | 0.5 | 33 | 1.7 (1.1–2.2) | 5380 | 0.61 | 67 | 3.1 (2.4–3.8) | 5866 | 1.14 | .008 |
| Nonfatal stroke | 22 | 1.0 (0.6–1.4) | 5786 | 0.38 | 26 | 1.3 (0.8–1.8) | 5382 | 0.48 | 52 | 2.4 (1.7–3.0) | 5875 | 0.89 | .001 |
| Total MI | 108 | 4.8 (3.9–5.7) | 5782 | 1.87 | 100 | 5.1 (4.1–6.0) | 5380 | 1.86 | 185 | 8.5 (7.3–9.7) | 5865 | 3.15 | <.001 |
| Total stroke | 34 | 1.5 (1.0–2.0) | 5786 | 0.59 | 33 | 1.7 (1.1–2.2) | 5384 | 0.61 | 70 | 3.2 (2.5–4.0) | 5875 | 1.19 | <.001 |
Abbreviation: CI, confidence interval; MI, myocardial infarction.
a
P value for comparison of event rate per 100 patient-years, between systolic blood pressure categories.
b
Primary outcome is defined as the first occurrence of all-cause death, nonfatal MI, or nonfatal stroke.