Table 1.

Summary of Clinicopathologic Profile of Patients Prior to Conversion and Outcome After Switch to FK 506, Based on at Least 9 Months Follow-Up

Pre–FK 506 Diagnosis	No. Patients	Died	Retransplanted	Functioning	Histologic Follow-Up			Biochemical Parameters of Liver Injury After Conversion¶
					Improved	No Change	Worse
Acute cellular rejection	18	3	1	14	10	4	0	Improved
Chronic rejection	33	0	11*	22†	13	9	0	Improved
Chronic rejection‡  CPH/CAH	20	0	4	16	1	10	5	Mixed
Hepatitis§	7	4	1	2	0	0	2	Worse
Nonspecific changes||	18	0	0	18	0	18	0	Same

^*Seven/11 patients had >50% bile duct loss and total serum bilirubin > 15 mg/dL prior to conversion.

^†All but 2 patients had <50% bile duct loss and total serum bilirubin <15 mg/dL prior to conversion.

^‡Initial cause of graft malfunction was uncertain. Difficulty in separating ongoing rejection from chronic persistent (CPH) or low-grade chronic active hepatitis (CAH) was encountered.

^§Acute and chronic active.

^||Patients were switched primarily for reasons other than graft dysfunction.

^¶Based on examination of functioning grafts 180 days after conversion.