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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Mol Cancer Ther. 2010 Jul 27;9(8):2232–2242. doi: 10.1158/1535-7163.MCT-10-0336

Figure 5. 17-DMAG attenuates the levels of TrkA and inhibits NGF-mediated neurite formation in PC-12 cells.

Figure 5

A. PC-12 cells were treated with indicated concentrations of 17-DMAG for 24 hours. Following this, total cell lysates were prepared and Western blot analyses were performed for TrkA and c-Raf. The levels of β-actin served as loading control. B. PC-12 cells were serum starved for 24 hours. Cells were then treated with 100ng/ml NGF or co-treated with NGF and 1.0 μM, 17-DMAG for 24 hours. Following this, neurite formation was evaluated utilizing light microscopy and images were acquired with digital camera.