TABLE 1.

Results for HPV16, -18, and -45 E6 oncoprotein detection among specimens positive for HPV16/18/45 DNA^a

Histological diagnosis or scoreb	No. of specimens with the following test resultc:						No. of specimens positive for HPV16/18/45d		% HPV E6-positive/DNA-positive specimens (95% CI)e
	HPV16		HPV18		HPV45		DNA	E6
	DNA	E6	DNA	E6	DNA	E6
Negative	6	0	1	0	2	0	8	0	0 (0-37)
CIN1	8	0	0	0	0	0	8	0	0 (0-37)
CIN3	29	15	5	3	0	2f	34	20	59 (41-75)
CIN3+g	24	12	5	4	3	1	25	17	68 (46-85)
Cancer	15	13	1	1	0	1f	16	14	62-98
≤CIN1	14	0	1	0	2	0	16	0	0 (0-37)
CIN3+	68	40	11	8	3	4	75	51	68 (56-78)
Total	82	40	12	8	5	4	91	51	56 (45-66)

^aThe results of HPV16, -18, and -45 E6 oncoprotein detection are stratified by the severity of histologic diagnosis.

^bCIN1, cervical intraepithelial neoplasia grade 1; CIN3, cervical intraepithelial neoplasia grade 3; CIN3+, CIN3 or cancer.

^cThe numbers of specimens with test results (negative test result or various CIN grades or cancer) for HPV16, HPV18, and HPV45 by DNA or E6 oncoprotein detection are shown.

^dThe number of specimens positive for HPV16, -18, or -45 (HPV16/18/45) by DNA or E6 oncoprotein detection are shown.

^eThe percentage of HPV E6-positive specimens among DNA-positive specimens and binomial 95% confidence interval (95% CI) are shown.

^fHPV16 DNA positive.

^gReported as CIN3+ (did not differentiate whether the diagnosis was CIN3 or cervical cancer). Three cases were HPV18 E6 positive but were HPV18 DNA negative and HPV16 DNA positive.