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. 2010 Oct 13;48(12):4453–4458. doi: 10.1128/JCM.00953-10

TABLE 3.

Predictions of the four genotypic approachesa

Patient no. Sample Prediction by:
G2P PSSM SVM C4.5 MCT TROCAI
1 Serum CCR5 CCR5 D/M CCR5 + R5
2 Serum CCR5 CCR5 CCR5 CCR5 + R5
V-Iso D/M D/M D/M CCR5 + R5
3 Serum CCR5 CCR5 CCR5 CCR5 + R5
V-Iso CCR5 CCR5 CCR5 CCR5 + R5
P-DNA CCR5 CCR5 CCR5 CCR5 + R5
4 Serum CCR5 CCR5 CCR5 CCR5 + R5
V-Iso CCR5 CCR5 CCR5 CCR5 + R5
P-DNA CCR5 CCR5 D/M CCR5 + R5
5 Serum CCR5 CCR5 CCR5 CCR5 + R5
V-Iso CCR5 CCR5 CCR5 CCR5 + R5
P-DNA CCR5 CCR5 CCR5 CCR5 + R5
6 Serum No sample No sample No sample No sample + R5
7 Serum CCR5 CCR5 CCR5 CCR5 + R5
8 Serum CCR5 CCR5 CCR5 CCR5 + R5
9 Serum No sample No sample No sample No sample + R5
10 Serum CCR5 CCR5 CCR5 CCR5 + R5
11 Serum D/M CCR5 CCR5 CCR5 + R5
12 Serum CCR5 D/M CCR5 CCR5 + R5
13 Serum CCR5 CCR5 CCR5 CCR5 + R5
P-DNA CCR5 CCR5 CCR5 CCR5 + R5
14 Serum CCR5 CCR5 CCR5 CCR5 + R5
15 Serum CCR5 CCR5 CCR5 CCR5 + R5
P-DNA CCR5 CCR5 CCR5 CCR5 + R5
16 Serum CCR5 CCR5 CCR5 CCR5 + R5
17 Serum CCR5 CCR5 CCR5 CCR5 + R5
18 Serum Not amplified Not amplified Not amplified Not amplified + R5
19 Serum CCR5 CCR5 CCR5 CCR5 + R5
20 Serum CCR5 CCR5 CCR5 CCR5 + NA
21 Serum Not amplified Not amplified Not amplified Not amplified + NA
22 Serum Not amplified Not amplified Not amplified Not amplified + NA
23 Serum D/M D/M D/M D/M − D/M
24 Serum D/M D/M D/M CCR5 − D/M
25 Serum D/M D/M D/M D/M − D/M
26 Serum D/M D/M CCR5 CCR5 − D/M
V-Iso D/M D/M CCR5 CCR5 − D/M
P-DNA D/M D/M CCR5 CCR5 − D/M
27 Serum CCR5 CCR5 CCR5 CCR5 − D/M
V-Iso CCR5 CCR5 CCR5 CCR5 − D/M
P-DNA D/M D/M CCR5 CCR5 − D/M
28 Serum CCR5 CCR5 D/M CCR5 − D/M
V-Iso CCR5 CCR5 CCR5 CCR5 − D/M
29 Serum D/M CCR5 CCR5 CCR5 − D/M
30 Serum D/M D/M D/M D/M − D/M
P-DNA D/M D/M D/M D/M − D/M
31 Serum Not amplified Not amplified Not amplified Not amplified − D/M
32 Serum D/M D/M D/M D/M − D/M
33 Serum D/M CCR5 CCR5 CCR5 − D/M
a

G2P, geno2pheno algorithm; PSSM, PSSM algorithm; C4.5, C4.5 algorithm; SVM, SVM algorithm; MCT, maraviroc clinical test; V-Iso, virus isolates; P-DNA, proviral DNA; NA, not available.