TABLE 2.
HBV subgenotypes in relation to clinical features in patients with chronic HBV infection (n = 4,118)
| HBV subgenotype | No. of cases | % | Mean age (yr) ± SD | No. male | Mean HBV DNA (log IU/ml) ± SD | Mean TBIL (μmol/liter) ± SD | Mean PTA (%) ± SD | Mean ALT (IU/liter) ± SD | Mean AST (IU/liter) ± SD | % HBeAg+ |
|---|---|---|---|---|---|---|---|---|---|---|
| B1 | 15 | 0.36 | 31 ± 12 | 15 | 4.3 ± 1.7 | 17.0 ± 5.7 | 88.0 ± 11.7 | 56 ± 49 | 38 ± 29 | 33.3 |
| B2 | 550 | 13.35 | 34 ± 13 | 475 | 5.2 ± 1.7 | 19.7 ± 34.6 | 83.2 ± 23.3 | 92 ± 176 | 63 ± 103 | 60.5 |
| B3 | 10 | 0.24 | 40 ± 14 | 7 | 4.5 ± 1.3 | 17.4 ± 9.0 | 88.0 ± 15.4 | 5 ± 42 | 59 ± 57 | 40 |
| B4 | 14 | 0.34 | 33 ± 15 | 10 | 5.0 ± 2.0 | 30.0 ± 52.9 | 92.4 ± 13.4 | 160 ± 261 | 86 ± 119 | 64.3 |
| C1 | 43 | 1.04 | 38 ± 13 | 36 | 5.4 ± 1.7 | 30.8 ± 55.1 | 76.1 ± 16.9 | 84 ± 143 | 80 ± 153 | 69.8 |
| C2 | 3,404 | 82.66 | 40 ± 13 | 2,854 | 5.1 ± 1.7 | 25.6 ± 53.3 | 79.5 ± 21.5 | 84 ± 144 | 67 ± 94 | 64.3 |
| C3 | 39 | 0.95 | 37 ± 12 | 32 | 5.3 ± 1.5 | 15.9 ± 9.1 | 82.2 ± 16.5 | 74 ± 78 | 61 ± 59 | 79.5 |
| C4 | 7 | 0.17 | 29 ± 12 | 6 | 5.0 ± 1.7 | 8.3 ± 2.8 | 88.3 ± 10.4 | 46 ± 41 | 45 ± 44 | 71.4 |
| D | 36 | 0.87 | 35 ± 14 | 28 | 5.2 ± 1.9 | 16.7 ± 10.9 | 80.0 ± 14.6 | 100 ± 168 | 69 ± 114 | 58.3 |
| Pa | <0.01 | 0.2 | 0.64 | 0.68 | 0.75 | 0.33 | 0.18 | 0.01 |
a
The P values were obtained from comparison of parameters between HBV subgenotypes B2 and C2 and evaluated by multivariate analysis.