TABLE 3.
Characteristics of K. pneumoniae isolates used in this study
| K. pneumoniae group | No. of isolates | Area (yr) of detection | Notea | Reference or source |
|---|---|---|---|---|
| WT | 43 | Cleveland, OH (2009) | Isolates were resistant to ampicillin only; molecular characterization was not performed | This study |
| ESBL producers | 20 | Intercontinental distribution (1996-1997) | The following blaESBL genes were detected: blaTEM-10 (n = 3), blaTEM-63 (n = 1), blaSHV-2 (n = 5), blaSHV-5 (n = 12), blaCTX-M-2 (n = 1), and blaPER-1-like (n = 2) | 35 |
| 22 | Pittsburgh, PA (2005-2006), Cleveland, OH (2007) | The following blaESBL genes were detected: blaSHV-2 (n = 2), blaSHV-5 (n = 3), blaSHV-5-like (n = 9), blaSHV-7 (n = 2), blaSHV-12 (n = 2), blaTEM-10-like (n = 3), and blaCTX-M-2-like (n = 3) | This study | |
| ESBL producers with OmpK loss | 18 | Pittsburgh, PA (2005-2006), Cleveland, OH (2007) | The following blaESBL or blaAmpC genes were detected: blaSHV-2 (n = 1), blaSHV-5 (n = 6), blaSHV-5-like (n = 5), blaSHV-12 (n = 5), blaSHV-75 (n = 1), blaCTX-M-2-like (n = 4), and blaCMY-2-like (n = 1); 10 isolates did not possess complete ompK36 and ompK37 genes, and 8 isolates did not possess a complete ompK35 gene | This study |
| KPC producers | 42 | Eastern USA (2006-2007) | The following bla genes were detected: blaKPC-2 (n = 25), blaKPC-3 (n = 17), blaSHV-5 (n = 1), blaSHV-11 (n = 40), blaSHV-12 (n = 21), blaSHV-14 (n = 1), blaSHV-26 (n = 1), blaSHV-68 (n = 1), and blaTEM-1 (n = 38) | 12-16 |
a
Some isolates possess more than one blaESBL gene.