TABLE 1.
Main clinical features of infections and colonization by Acinetobacter genospecies 3 and Acinetobacter baumannii
| Characteristic of patientsa | No. of cases with patient characteristic/total cases (%) or median value ± SDb |
P valuec | |
|---|---|---|---|
| Acinetobacter genospecies 3 | Acinetobacter baumannii | ||
| Demographic features | |||
| Age | 56 ± 20.7 | 60 ± 20.3 | 0.8 |
| Female gender | 4/13 (30.8) | 60/212 (28.3) | 1.0 |
| Any comorbidity | 9/13 (69.2) | 152/212 (71.7) | 1.0 |
| Diabetes mellitus | 5/13 (38.5) | 32/212 (15.1) | 0.04 |
| Neoplastic disease | 2/13 (15.4) | 35/212 (16.5) | 1.0 |
| Obesity | 0/13 (0) | 20/212 (9.4) | 0.6 |
| Hepatopathy | 0/13 (0) | 8/212 (3.8) | 1.0 |
| Renal insufficiency | 1/13 (7.7) | 10/212 (4.7) | 0.5 |
| COPD | 2/13 (15.4) | 28/212 (13.2) | 0.7 |
| Heart failure | 2/13 (15.4) | 26/212 (12.3) | 0.7 |
| Transplantation | 0/13 (0) | 4/212 (1.9) | 1.0 |
| Immunosuppression | 1/13 (7.7) | 14/212 (6.6) | 0.6 |
| Predisposing external factors | |||
| Central venous catheter | 5/13 (38.5) | 139/211 (65.6) | 0.07 |
| Urinary catheterization | 7/13 (53.8) | 164/211 (77.4) | 0.08 |
| Recent surgery | 3/13 (23.1) | 101/211 (47.6) | 0.09 |
| Parenteral nutrition | 0/13 (0) | 53/211 (25) | 0.04 |
| Previous ICU admission | 4/13 (30.8) | 145/212 (68.4) | 0.01 |
| Mechanical ventilation | 3/13 (23.1) | 115/211 (54.2) | 0.04 |
| Previous antibiotic therapy | 7/13 (53.8) | 166/210 (79) | 0.07 |
| No. of previous antimicrobial agents | 0.5 ± 1.2 | 2 ± 6.9 | 0.03 |
| Clinical features | |||
| Nosocomial acquisition | 10/13 (76.9) | 206/212 (97.2) | 0.01 |
| Days of stay prior to the isolation | 4 ± 11.4 | 15 ± 27.9 | 0.02 |
| Cases from ICU | 2/13 (15.4) | 106/212 (50) | 0.02 |
| Type of sample | |||
| Respiratory sample | 2/13 (15.4) | 85/209 (40.7) | 0.08 |
| Blood/catheter culture | 1/13 (7.7) | 17/209 (8.1) | 1.0 |
| Urine culture | 3/13 (23.1) | 50/209 (23.9) | 1.0 |
| Wound swab or abscess culture | 6/13 (46.1) | 48/209 (22.9) | 0.08 |
| Infection/colonization | |||
| Colonization | 5/12 (41.6) | 98/212 (46.2) | 0.7 |
| Infection | 7/12 (58.3) | 114/212 (53.8) | 0.7 |
| Site of infection* | |||
| Respiratory tract* | 1/7 (14.3) | 55/112 (49.1) | 0.1 |
| Urinary tract* | 1/7 (14.3) | 17/112 (15.2) | 1.0 |
| Skin/soft tissue* | 4/7 (57.1) | 24/112 (11.3) | 0.05 |
| Bloodstream* | 1/7 (14.2) | 8/112 (7.1) | 0.4 |
| Incorrect empirical treatment* | 1/7 (14.3) | 38/110 (34.5) | 0.4 |
| Severe sepsis or septic shock* | 0/7 (0) | 29/111 (26.1) | 0.2 |
| Days of stay after isolation | 16 ± 11.2 | 20 ± 11.1 | 0.4 |
| Crude mortality | |||
| All cases | 1/11 (9.1) | 39/209 (18.7) | 0.7 |
| Infection cases* | 0/7 (0) | 29/112 (26.1) | 0.2 |
a
COPD, chronic obstructive pulmonary disease. Only infection cases were included for the analysis of variables marked with “*” (colonization cases excluded).
b
Continuous variables are expressed as median values ± standard deviations. When the total for a variable is expressed as a value inferior to the total number of cases, this corresponds to unavailable data. For Acinetobacter genospecies 3, n = 13 cases; for Acinetobacter baumannii, n = 212 cases.
c
Statistically significant values are in boldface.