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Individual and mean (horizontal line) values of RVSP in normoxic 5-HTT+/+ and 5-HTT–/– mice under ventilation with room air (normoxia) and after 5 minutes of ventilation with a hypoxic gas mixture (hypoxia). Baseline RVSP under normoxic ventilation did not differ between 5-HTT+/+ and 5-HTT–/– mice. The RVSP increase during acute hypoxia was significantly larger in 5-HTT–/– than in 5-HTT+/+ mice (P < 0.01).
