A. LV mass (grams); B. LV stroke volume (mL); C. LV end-diastolic volume (mL). Open square = anti-CCP < median (128 units), no current biologics; Solid square = anti-CCP < median, current biologics used; Open diamond = anti-CCP > median, no current biologics; Solid diamond = anti-CCP > median, current biologics used. Means and 95% confidence intervals are depicted. Red Solid horizontal line = Adjusted mean for the control group; Red horizontal dashed line = 95% confidence limit for the adjusted mean for the control group. Adjusted for body surface area, age, gender, systolic blood pressure, antihypertensive use, and current smoking. DMARD=disease modifying anti-rheumatic drug; LV=left-ventricular