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. Author manuscript; available in PMC: 2011 Sep 24.
Published in final edited form as: Vaccine. 2010 Aug 4;28(41):6740–6748. doi: 10.1016/j.vaccine.2010.07.075

Figure 4.

Figure 4

Antibody responses in mice immunized with LF domains. (A) LF-specific IgG antibody and (B) toxin neutralizing activity (TNA) titers in mice immunized with LF domains. BALB/c mice (10 per group) received 10 µg of each domain protein adsorbed to alum via i.m. on days 0 and 28. Results are expressed as LF geometric mean IgG titers with 95% confidence intervals. TNA titers are shown as mean with range; ED50 was <100 for LFD3 and LFD4 groups. Vertical lines indicate immunization days. LF IgG titers among the different groups were compared at day 56 after immunization (peak); * denotes higher responses for LF vs. all other groups, higher responses for LFD1 vs. LFD3 but lower compared with all other groups, and lowest responses for LFD3 vs. all other groups (p<0.05). For TNA titers, * denotes higher responses to PA vs. LF (p<0.001) and ** higher responses to LF vs. all other domains (p<0.05)