Figure 3.

Immunohistochemical staining for late macrophage invasion (28 days) after balloon injury and saline control treatment in the rat iliofemoral artery (a). M-T7–treated sections (1.7 pg/g) of rat iliofemoral artery had a marked decrease in plaque area and macrophage invasion at 28 days’ follow-up (b). An early increase in macrophage invasion into the medial and adventitial layers was detected at 24 hours’ follow-up after angioplasty injury in saline-treated rat controls (c). M-T7 treated (1.7 pg/g) sections also demonstrated an early reduction in macrophage staining in the rat iliofemoral artery sections taken at 24 hours’ follow-up on comparison with the control-treated rats (d). Bar graphs demonstrate decreased adventitial areas staining positive for macrophages (e) and smooth muscle cells (f) in the rat balloon-injury model at early and late follow-up. C, saline control treated; T7, M-T7 treated. ×1,000.