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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: Front Neuroendocrinol. 2010 Jul 30;32(1):43–52. doi: 10.1016/j.yfrne.2010.07.005

Figure 1.

Figure 1

Heparan sulfate proteoglycans: role in modulating ligand activation of membrane receptors. Expanding data suggests that certain ligands or their receptors with fibonectin domains or similar regions are modulated by classes of heparan sulfate proteoglycans (HSPGs) (eg. in c. elegans, syndecan-1 or glipican-1) with specific HS to control ligand activation. These include potential interactions with Gas6/Axl or Tyro3 and documented interactions with HGF/cMET, netrin/DCC, FGF8/FGFR1, anosmin and PROK2/PROKR2.