Table 1.

Factors implicated in GnRH neuron migration. List of matrix proteins, secreted proteins, transcription factors, membrane receptors and ligands and transcription factors implicated in GnRH neuron development.

Cell Matrix/Adhesion	Neuro-transmitters	Growth Factors	G-Protein Coupled Receptors	Transcription Factors	Other
Neural cell adhesion molecule (NCAM)	GABA/GABA-A and GABA-B	FGF8/FGFR1	PROK2/PROKR2	Ebf2	NELF
Cell surface proteoglycans (eg. B3GNT1)	Cholecystokinin-8 (CCK8)/ CCK1R	Gas6/ Axl and Tyro3	SDF1/CXCR4	Nhlh2
Anosmin (KAL1)		HGF/Met	Kiss/KissR
Heparan sulfate Proteoglycans
Ephrins/Ephrin receptors
Semaphorin 4D/PlexinB1
Semaphorin3a/Neuropilin2/PlexinA1
Netrin/DCC
Reelin/ApoER2/Lrp8

B3GNT1- BetaGal beta-1,3-N-acetylglucosaminyltransferase 1; KAL 1 – Kallmann 1; DCC-Deleted in colorectal cancer gene; ApoER2- Apolipoprotein E receptor 2; Lrp8- Low density lipoprotein receptor-related protein 8; GABA- Gamma-Aminobutyric acid; CCK1R- Cholecystokinin-1 receptor; FGF8- Fibroblast growth factor 8; FGFR1- Fibroblast growth factor receptor 1; Gas6- Growth arrest specific gene 6; HGF- Hepatocyte growth factor; PROK2-Prokineticin 2; PROKR2-Prokineticin 2 receptor; SDF1 - Stromal cell derived factor 1; CXCR4- chemokine (C-X-C motif) receptor 4; Kiss- Kisspeptin; KissR- Kisspeptin receptor; Ebf2- Early B-cell factor 2; Nhlh2- Nescient helix loop helix 2; NELF- Nasal embryonic LHRH factor