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. Author manuscript; available in PMC: 2010 Dec 22.
Published in final edited form as: Cancer Cell. 2009 Dec 8;16(6):521–532. doi: 10.1016/j.ccr.2009.10.018

Figure 1. Identification and Validation of a Prognostic Gene Expression Signature Correlating with Survival in 53 Microdissected Late-Stage High-Grade Papillary Serous Ovarian Tumors.

Figure 1

(A) Hierarchical clustering of 53 advanced stage, high-grade serous adenocarcinomas using expression values for genes possessing a Cox score >10 (gene expression: red, upregulated; blue, downregulated; survival: blue, short survival; red, long survival).

(B) Genes presented in this table possessed a large Cox score (>10). Only the probe set with the highest Cox score is presented for MAGP2.

(C) Kaplan Meier analysis of the predictor demonstrated a significant difference in survival time (p = 0.0029).

(D) Kaplan Meier survival analysis of 49 patients using qRT-PCR validation data obtained for the top 11 survival-signature genes confirmed the two groups retained significantly different survival endpoints (p = 0.0107).

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