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. Author manuscript; available in PMC: 2010 Dec 22.
Published in final edited form as: Cancer Cell. 2009 Dec 8;16(6):521–532. doi: 10.1016/j.ccr.2009.10.018

Figure 6. Identification of Putative Signaling Events Mediating the Effects of MAGP2 on HUVECs.

Figure 6

(A) Hierarchical clustering of recMAGP2-treated (n = 3) and untreated (n = 3) HUVECs following supervised class comparison. The top 50 differentially regulated probe sets are displayed (red, upregulated; blue, downregulated).

(B) Signaling events stimulated in HUVECs treated with recMAGP2 as compared to untreated cells. Differentially regulated genes were identified (red, upregulated; blue, downregulated; gray, no change).

(C) recMAGP2 treatment of HUVECs increased the proportion of phosphorylated FAK, as compared to untreated cells. Error bar represents the area/second mean ± SD of three independent experiments.

(D) Time course changes in [Ca2+] levels in a single recMAGP2 induced in a single HUVEC.

(E) Mean normalized time course changes in [Ca2+] induced by recMAGP2 in HUVECs.

(F) Mean normalized time course of changes in [Ca2+] induced by recMAGP2 in HUVECs pre-treated with GRGDSP competitor peptide.