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. Author manuscript; available in PMC: 2010 Dec 22.
Published in final edited form as: Bull Math Biol. 2009 Dec 16;72(3):611–644. doi: 10.1007/s11538-009-9463-1

Fig. 3.

Fig. 3

The time-division based program (5)–(6). APCs and naïve cells are modeled in the same way as in the cell division-based program. (1) Naïve T cells, T0, are stimulated by mature APCs and enter the pool of cells undergoing a minimal developmental program, denoted by T1/2. (2) After σ units of time (the duration of the minimal program) cells enter the effector state, T1, after having divided m times. (3) Cells live in the effector state for τ units of time before committing apoptosis. (4) As an ongoing step, effector cells repeatedly get stimulated by mature APCs and enter the dividing population, T2, where they spend ρ units of time (the duration of one cell division) before returning to the effector state after having divided once.