Table 1. Summary tablea.
|
G396D
|
Y179C
|
Genotype
|
Age |
Sex
|
Ethnicity
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Study | Number | GG | GA | AA | AA | AG | GG | WW | WM | MM | n (%) | Mean (SD) | n (%) | Males (%) | n (%) | Caucasian/White (%) |
| All studies | ||||||||||||||||
| Cases | 20 565 | 19 966 | 324 | 33 | 20 260 | 154 | 11 | 19 783 | 417 | 76 | 20 555 (99.9) | 59.5 (10.1) | 20 555 (99.9) | 11 668 (56.8) | 5374 (26.1) | 5030 (93.6) |
| Controls | 15 524 | 15 145 | 211 | 0 | 15 074 | 68 | 2 | 14 723 | 280 | 2 | 15 287 (98.5) | 59.0 (10.9) | 15 521 (99.9) | 6845 (44.1) | 5597 (36.1) | 4796 (85.7) |
| Croitoru et al (2004) | ||||||||||||||||
| Cases | 1238 | 1209 | 25 | 4 | 1223 | 13 | 2 | 1197 | 29 | 12 | 1236 (99.8) | 60.1 (8.7) | 1236 (99.8) | 544 (44.0) | Missing | Missing |
| Controls | 1255 | 1238 | 17 | 0 | 1251 | 4 | 0 | 1234 | 21 | 0 | 1244 (99.1) | 63.6 (8.6) | 1252 (99.8) | 702 (56.1) | Missing | Missing |
| Peterlongo et al (2005) | ||||||||||||||||
| Cases | 585 | 567 | 3 | 1 | 569 | 3 | 0 | 552 | 4 | 2 | 584 (99.8) | 62.1 (13.1) | 584 (99.8) | 319 (54.6) | 585 (100) | 251 (42.9) |
| Controls | 1158 | 1040 | 5 | 0 | 1039 | 2 | 0 | 923 | 7 | 0 | 1148 (99.1) | 53.9 (11.5) | 1156 (99.8) | 240 (20.8) | 1158 (100) | 363 (31.3) |
| SOCCS (includes data from Farrington et al (2005), Tenesa et al (2006) and unpublished SOCCS prospective samples) | ||||||||||||||||
| Cases | 3278 | 3086 | 55 | 8 | 3192 | 23 | 0 | 3038 | 71 | 12 | 3277 (100) | 59.5 (11.3) | 3278 (100) | 1883 (57.4) | 3278 (100) | 3268 (99.7) |
| Controls | 3318 | 3239 | 43 | 0 | 3061 | 15 | 0 | 2993 | 57 | 0 | 3313 (99.8) | 61.4 (10.9) | 3318 (100) | 1861 (56.1) | 3318 (100) | 3312 (99.8) |
| Moreno et al (2006) | ||||||||||||||||
| Cases | 356 | 343 | 8 | 1 | 348 | 0 | 0 | 336 | 8 | 1 | 356 (100) | 66.5 (11.7) | 356 (100) | 217 (61.0) | Missing | Missing |
| Controls | 297 | 285 | 7 | 0 | 291 | 0 | 0 | 283 | 7 | 0 | 297 (100) | 65.3 (12.5) | 297 (100) | 158 (53.2) | Missing | Missing |
| Koessler T, (unpublished data obtained in 2007) | ||||||||||||||||
| Cases | 2262 | 2215 | 31 | 2 | 2227 | 19 | 1 | 2198 | 37 | 9 | 2253 (99.6) | 59.1 (8.1) | 2262 (100) | 1287 (57.1) | Missing | Missing |
| Controls | 2253 | 2217 | 31 | 0 | 2236 | 11 | 0 | 2204 | 42 | 0 | 2053 (91.1) | 53.4 (7.6) | 2253 (100) | 949 (42.0) | Missing | Missing |
| Küry et al (2007) | ||||||||||||||||
| Cases | 1025 | 1003 | 22 | 0 | 1021 | 4 | 0 | 999 | 25 | 1 | 1023 (99.8) | 68.7 (9.9) | 1025 (100) | 632 (61.7) | 1025 (100) | 1025 (100) |
| Controls | 1121 | 1105 | 16 | 0 | 1117 | 4 | 0 | 1100 | 21 | 0 | 1121 (100) | 61.9 (10.0) | 1121 (100) | 609 (54.3) | 1121 (100) | 1121 (100) |
| SOCCS retrospective cases (unpublished data obtained in 2008) | ||||||||||||||||
| Cases | 486 | 403 | 6 | 2 | 446 | 2 | 3 | 391 | 6 | 4 | 486 (100) | 54.7 (17.2) | 479 (98.6) | 240 (50.1) | 486 (100) | 486 (100) |
| Controls | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||
| Cleary et al (2009) | ||||||||||||||||
| Cases | 2076 | 2023 | 33 | 5 | 2053 | 7 | 1 | 2029 | 38 | 9 | 2070 (99.7) | 56.6 (10.8) | 2076 (100) | 1114 (53.7) | Missing | Missing |
| Controls | 1049 | 1032 | 17 | 0 | 1042 | 6 | 1 | 1024 | 24 | 1 | 1047 (99.8) | 56.4 (11.3) | 1049 (100) | 444 (42.3) | Missing | Missing |
| Lubbe et al (2009) b | ||||||||||||||||
| Cases | 9268 | 9117 | 141 | 10 | 9181 | 83 | 4 | 9043 | 198 | 27 | 9268 (100) | 59.0 (8.5) | 9268 (100) | 5432 (58.6) | Missing | Missingc |
| Controls | 5064 | 4989 | 75 | 0 | 5037 | 26 | 1 | 4962 | 101 | 1 | 5064 (100) | 59.2 (10.8) | 5064 (100) | 1882 (37.2) | Missing | Missingc |
Abbreviations: MM=mutated/mutated; WM=wild type/mutant; WW=wild type/wild type.
a
This table presents the raw data sent to us by each group that was then included in the analyses. G396D and Y179C are looked at independently and any compound bi-allelic carriers are presented as heterozygotes for each variant; MUTYH genotype data also includes other pathogenic mutations; unpublished data are included in Peterlonogo P and Moreno V, SOCCS prospective and Küry S.
b
Includes data from Webb et al (2006) and Fleischmann et al (2004).
c
All the cases and controls were UK residents and of European ancestry (self-reported).