Table 4. Meta-analysis of studies for the G396D genotypesa.

	G396D (cases)			G396D (controls)			GA vs GG	AA vs GG
Study	GG	GA	AA	GG	GA	AA	OR (95% CI)	OR (95% CI)
Enholm et al (2003)	994	4	1	424	0	0	3.84 (0.21, 71.51)	1.28 (0.05, 31.50)
Kambara et al (2004)	90	2	0	52	—	0	Not enough data available	NA
Wang et al (2004)	432	5	0	309	2	0	1.79 (0.35, 9.28)	NA
Zhou et al (2005)	432	1	0	466	1	0	1.08 (0.07, 17.30)	NA
Peterlongo et al (2005)	549	2	0	911	5	0	0.66 (0.13, 3.43)	NA
Tomlinson I (2006)b	662	9	1	197	2	0	1.34 (0.29, 6.25)	0.89 (0.04, 22.04)
Moreno et al (2006)	323	9	0	278	6	0	1.29 (0.45, 3.67)	NA
Colebatch et al (2006)	859	8	0	473	4	0	1.10 (0.33, 3.67)	NA
Koessler T (2007)c	2198	25	2	2204	31	0	0.81 (0.48, 1.37)	5.01 (0.24, 104.49)
Küry et al (2007)	999	21	0	1100	16	0	1.45 (0.75, 2.79)	NA
Balaguer et al (2007)	1089	15	1	912	20	0	0.63 (0.32, 1.23)	2.51 (0.10, 61.75)
SOCCS (2008)d	3429	56	8	2993	42	0	1.16 (0.78, 1.74)	14.84 (0.86, 257.19)
Avezzù et al (2008)	435	2	1	246	0	0	2.83 (0.14, 59.19)	1.70 (0.07, 41.84)
Cleary et al (2009) e	3697	63	11	2758	32	0	1.47 (0.96, 2.25)	17.16 (1.01, 291.31)
Lubbe et al (2009) f	9043	128	10	4962	75	0	0.94 (0.70, 1.25)	11.52 (0.68, 196.69)
M–H pooled effect (fixed)	25 231	350	35	18 285	236	0	1.07 (0.90, 1.26)	6.47 (2.33, 17.97)
P-value							0.44	<0.0005
Heterogeneity
P-value							0.74	0.73
I2 (95% CI)							0 (0, 55)	0 (0, 68)

Abbreviations: CI=confidence interval; MM=mutated/mutated; NA=not available; OR=odds ratio; WM=wild type/mutant; WW=wild type/wild type.

^aThis table presents the data as they were published. Two unpublished studies included.

^bUnpublished data obtained in 2006.

^cUnpublished data obtained in 2007.

^dIncludes data from Farrington et al (2005), Tenesa et al (2006) and unpublished data from the SOCCS study obtained in 2008.

^eIncludes data from Croitoru et al (2004).

^fIncludes data from Webb et al (2006) and Fleischmann et al (2004).