Table 3. Anticancer drugs most often prescribed to patients in the study.
INN | No. of prescriptions | Percent of prescription (%) | Need for dosage adjustment in RI | Potential nephrotoxicity |
---|---|---|---|---|
Fluorouracil | 248 | 13.6 | No | No |
Zoledronate | 220 | 12.1 | Yes | Yes |
Docetaxel | 114 | 6.2 | Yes | No |
Cyclophosphamide | 101 | 5.5 | Yes | No |
Epirubicin | 94 | 5.2 | No | SC |
Trastuzumab | 92 | 5.0 | ND | SC |
Gemcitabine | 90 | 4.9 | No | Yes |
Cisplatin | 89 | 4.9 | Yes | Yes |
Carboplatin | 70 | 3.8 | Yes | Yes |
Paclitaxel | 63 | 3.5 | No | SC |
Oxaliplatin | 61 | 3.3 | No | Yes |
Irinotecan | 53 | 2.9 | No | Yes |
Doxorubicin | 52 | 2.8 | No | SC |
Capecitabin | 47 | 2.6 | Yes | No |
Letrozole | 42 | 2.3 | No | No |
Tamoxifen | 41 | 2.2 | No | SC |
Ibandronate | 35 | 1.9 | Yes | No |
Vinorelbine | 32 | 1.8 | Yes | No |
Exemestane | 30 | 1.6 | No | No |
Temozolomide | 22 | 1.2 | ND | No |
Cetuximab | 18 | 1.0 | No | Yes |
Other | 238 | 12.9 | Yes: 28.2% | Yes: 100 prescriptions |
ND: 31.5% | ND: 18 prescriptions | |||
No: 40.3% | No: 100 prescriptions | |||
Total | 1852 | 100 | Yes: 41.8% | Yes: 1043 prescriptions |
ND: 10.2% | ND: 18 prescriptions | |||
No: 47.9% | No: 791 prescriptions |
Abbreviations: INN=international non-proprietary name; ND=no data available in the literature for use in patient with RI or for nephrotoxicity; RI=renal insufficiency; SC=sparse cases.
Other: anticancer drugs that were prescribed in <1% of patients in the study (decreasing number of prescriptions): bevacizumab, gosereline, etoposide, fulvestrant, methotrexate, topotecan, anastrozole, dacarbazine, vinblastine, erlotinib, vinflunine, mitoxantrone, bicalutamide, mitomycine, megestrole, pamidronate, imatinib, ifosfamide, vaccine, bleomycin, lomustin, estramustin, fotemustin, gefitinib, leuproreline, octreotide, hydroxycarbamide, pemetrexed, triptoreline, sunitinib, panitumumab, thyrixine, cyproterone, carmustine, rituximab, streptozocine, matuzumab, sorafenib, lanreotide, ipilimumab.