Fig. 6.

Western diet increased voluntary wheel running of mice from High Runner (HR) lines by ∼52% (+36% duration of running, +18% average speed of running) during days 17–30 of wheel access, whereas it had no effect on control lines [standard diet (Std)] [data from Meek et al. (Meek et al., 2010)]. This stimulation of voluntary exercise is remarkable in particular because the lines have been at an apparent selection limit for ∼35 generations (see Kolb et al., 2010). Data are adjusted means + s.e.m.