Table 1. Serum HI titers against homologous and heterologous H5N1 strains in ferrets vaccinated with clinical grade material.
| Vaccine Dosea | Vaccination | HI titersd (95% CI) (number of responders) | |||
| Indo/5/05 (clade 2.1) | Turkey/Turkey/1/05 (clade 2.2) | Anhui/1/05 (clade 2.3) | VN/1203/04 (clade 1) | ||
| 0.7 µg VLP | 1st doseb | 17 (7–45)(4/5) | 23 (4–130)(4/5) | 5 (3–8)(1/5) | <10 (0/5) |
| 2nd dosec | 255 (94–691)(5/5) | 32 (6–178(4/5) | 48 (8–307)(4/5) | 21 (6–78)(4/5) | |
| 1.8 µg VLP | 1st doseb | 23 (16–34)(14/16) | 14 (7–29)(9/16) | 6 (4–8)(6/16) | 5 (5–6)(1/16) |
| 2nd dosec | 429 (204–902)(8/8) | 124 (61–252)(8/8) | 74 (26–210)(7/8) | 24 (9–67)(6/8) | |
| 3.7 µg VLP | 1st doseb | 27 (22–34)(16/16) | 31 (19–53)(15/16) | 6 (4–8)(6/16) | 6 (5–7)(1/16) |
| 2nd dosec | 382 (236–619)(8/8) | 78 (27–229)(7/8) | 78 (42–145)(8/8) | 28 (11–71)(7/8) | |
| 11.0 µg VLP | 1st doseb | 40 (17–95)(5/5) | 19 (3–120)(3/5) | 5 (3–8)(1/5) | <10 (0/5) |
| 2nd dosec | 560 (234–1342)(5/5) | 106 (53–211)(5/5) | 97 (54–173)(5/5) | 42 (16–113)(5/5) | |
a
All vaccines were formulated with Alhydrogel 1% (0.5 mg per dose).
b
HI titers measured 21 days after vaccination.
c
HI titers measured 14 days after boost vaccination.
d
Geometric Mean Titer measured on all animals. HI negative animals were given an arbitrary value of 4 or 5 depending on starting dilution in the HI assay.