Table 3. Multivariate Cox proportional hazards analysis for molecular markers and clinicopathological parameters.

	Disease-Specific Survival
Covariate (n = 323)	hazard ratio	(95% CI)	p -values
RB1CC1/RB1/p53 IHC (normal vs abnormal)	3.951	1.566–9.967	0.0036
Subtype ER/PR/HER2 (others vs triple negative)	1.974	1.038–3.754	0.0382
Stage: TNM class (≤IIA vs IIB≤)	2.188	1.149–4.167	0.0171
Chemotherapy (none vs performed)	2.242	1.012–4.950	0.0465

The Cox's model was used to evaluate any independent prognostic effect of the variables on disease-specific survival (DSS) with a 95% confidence interval (95% CI). p-value <0.05, statistically significant. DSS intervals were used as the indicator for the relative-hazards.