TABLE II.
Pharmacokinetic Parameters of FK 506
| Patient # | Distribution Rate Constant (hr−1) |
Disposition Rate Constant (hr−1) |
Disposition Half-Life (hr) |
Volume of Distribution at Steady State (L) |
Clearance (L/min) |
|---|---|---|---|---|---|
| 1 | 0.469 | 0.0975 | 7.1 | 822 | 1.56 |
| 2 | 0.453 | 0.0939 | 7.4 | 406 | 0.62 |
| 3 | 0.469 | 0.0889 | 7.8 | 1355 | 3.38 |
| 4 | 0.770 | 0.0276 | 25.1 | 1857 | 1.06 |
| 5 | 0.521 | 0.0439 | 15.8 | 573 | 0.47 |
| 6 | 3.10 | 0.0210 | 33.1 | 960 | 0.36 |
| 7 | 2.61 | 0.0225 | 30.7 | 2441 | 1.00 |
| 8 | 0.456 | 0.0878 | 7.9 | 1058 | 1.63 |
| 9 | 2.18 | 0.1555 | 4.5 | 1796 | 5.75 |
| Mean ± SD | 1.23 ± 1.08 | 0.0710 | 15.5 ± 11.2 | 1252 ± 668 | 1.76 ± 1.75 |
| 0.05 |