Figure 7. Voltage dependence of activation of Kv2.1/Kv9.3, but not Kv2.1, channels mimics that of native Kv current.

A, mean values ± s.e.m. for normalized tail current amplitude versus command step voltage for Kv2.1 and Kv2.1/Kv9.3 current at 22°C (n = 6 and 8, respectively). Note the negative shift in voltage dependence of Kv2.1/Kv9.3. B, mean values ± s.e.m. for normalized tail current amplitude versus command step voltage for Kv2.1 current at 22 and 35°C (n = 6 and 3, respectively). Dashed lines indicate the relation for activation of native current from Fig. 4E for comparison; note lack of similarity in voltage dependence of native and recombinant channel current activation at both recording temperatures. C, mean values ± s.e.m. for normalized tail current amplitude versus command step voltage for Kv2.1/Kv9.3 current at 22 and 35°C (n = 8 and 5, respectively). Dashed lines indicate the relation for activation of native current from Fig. 4E for comparison; note the similarity in voltage dependence of native and recombinant channel current activation at both recording temperatures.