Skip to main content
. 2010 Sep 20;588(Pt 22):4549–4562. doi: 10.1113/jphysiol.2010.191510

Figure 7. At least 30 min is required between FAT1 and FAT2 to trigger FPC.

Figure 7

All fatigue bouts consisted of one tetanic contraction every second for 3 min. Paired FDB bundles were used. For one bundle, FAT1 was elicited under control conditions (data not shown for clarity). FAT2 was then elicited in the presence of 10 μm glibenclamide at different times following FAT1 as indicated. For the paired muscle, delFAT1 was elicited at the same time as FAT2. Glibenclamide was added 30 min prior to FAT2, except for the time interval of 15 min when glibenclamide was added 15 min before FAT2 or delFAT1. tetanic force and unstimulated force at 30 s during FAT2 are expressed as a percentage of the pre-FAT1 tetanic force. Vertical bars represent the s.e.m. of 5 muscles. *Tetanic forces or unstimulated forces were significantly different between FAT2-Gli and delFAT1-Gli, ANOVA and LSD, P < 0.05.