Figure 1.

Schematic models representing the design of an experiment to identify the potential folding states of protein domains in the presence of detergent micelles (pink circles, detergent micelles; yellow circles, distance range detectable by PRE). (A) Detergents form a micelle on the transmembrane domain without affecting the folding state; (B) Detergents disrupt the overall folding states of extra-membrane and transmembrane domains. G (in blue circles) and P (in yellow circles) represent glycine residues and the paramagnetic probe, respectively.