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. Author manuscript; available in PMC: 2010 Dec 23.
Published in final edited form as: Int J Cancer. 2010 Oct 15;127(8):1866–1874. doi: 10.1002/ijc.25190

Table 2.

Gastric cancer risk and global hypomethylation in blood leukocytes

Methylation Cases
 Controls
 OR1 95% CI p-trend
No. % No. %
Alu (tertile)
25.7–31.6 96 31.8 153 36.3 1.0 (Reference) 0.19
24.5–<25.7 101 33.4 135 32.1 1.2 0.8–1.8
20.6–<24.5 105 34.8 133 31.6 1.3 0.9–1.9
Alu (continuous)2 302 421 1.1 0.8–1.7 0.52
LINE-1 (tertile)
81.7–90.4 96 32.0 145 34.6 1.0 (Reference) 0.12
78.6–<81.7 97 32.3 143 34.1 1.2 0.8–1.8
67.6–<78.6 107 35.7 131 31.3 1.4 0.9–2.0
LINE-1 (continuous)2 300 419 1.0 0.7–1.5 0.81
1

Adjusted for age, sex, educational level, smoking (never, former and current, or pack-years) and alcohol (nondrinker, former drinker or current drinker).

2

Odds ratio and 95% CI estimated from models including Alu or LINE-1 methylation as a continuous variable. The ORs and 95% CIs are scaled to express the risk increase associated with a decrease from the 90th to the 10th centile in Alu or LINE-1 DNA methylation.