Figure 6.

Localization of the residues discussed here in the crystal structure of GluA2 (PDB# 3KG2), with residue numbering, however, referring to the respective positions in GluA1. (A) Side view; (B) Top view; shown are the TMDs and the pore loop of two subunits of the tetramer as indicated by numbers in brackets; the TMD C of the second subunit was omitted for clarity. Side chains of residues investigated in this study are indicated. The tyrosine residue at position 793 is oriented away from the pore, facing the lipid bilayer. (C) Detailed top view; the phenylalanine residue at position 792 is oriented toward the pore and is in close proximity to C524 in TMD A and to F604 in TMD B of the neighboring subunit, suggesting an interaction between those residues and explaining the loss of function evoked by an exchange of F792 to alanine.