Table 4.
Kinase | New method | Kinase | New method | Kinase | New method | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|
ACC | P | R | ACC | P | R | ACC | P | R | |||
CDK_group | 0.92 | 0.60 | 0.88 | MAPK3 | 0.93 | 0.61 | 0.73 | CDK1 | 0.94 | 0.63 | 0.90 |
GSK-3_group | 0.88 | 0.32 | 0.17 | MAPK1 | 0.94 | 0.66 | 0.80 | CDK2 | 0.94 | 0.65 | 0.87 |
PLK1 | 0.90 | 0.00 | 0.00 | MAPK8 | 0.91 | 0.53 | 0.83 | CK2 alpha | 0.95 | 0.76 | 0.66 |
GRK_group | 0.91 | 0.15 | 0.07 | Lck | 0.92 | 0.75 | 0.20 | Lyn | 0.92 | 0.67 | 0.23 |
EGFR | 0.92 | 0.69 | 0.42 | PKC_group | 0.92 | 0.76 | 0.30 | RSK_group | 0.96 | 0.80 | 0.85 |
MAPK14 | 0.93 | 0.67 | 0.60 | Src | 0.92 | 0.69 | 0.27 | DNA-PK | 0.88 | 0.40 | 0.35 |
InsR | 0.93 | 0.62 | 0.45 | IGF1R | 0.95 | 0.76 | 0.70 | Aurora | 0.92 | 0.58 | 0.26 |
CK2_group | 0.94 | 0.71 | 0.58 | ATM | 0.96 | 0.87 | 0.70 | Met | 0.96 | 0.80 | 0.85 |
AMPK_group | 0.94 | 0.60 | 0.27 | Abl | 0.93 | 0.77 | 0.30 | PHK_group | 0.90 | 0.10 | 0.05 |
MAPKAPK2 | 0.92 | 0.63 | 0.33 | PDK-1 | 0.96 | 0.86 | 0.67 | GRK-2 | 0.94 | 0.30 | 0.15 |
CK1_group | 0.90 | 0.20 | 0.10 | PKA alpha | 0.95 | 0.78 | 0.57 | ROCK_group | 0.94 | 0.70 | 0.35 |
PKA_group | 0.95 | 0.81 | 0.59 | IKK_group | 0.91 | 0.43 | 0.20 | FGFR1 | 0.89 | 0.10 | 0.05 |
PKC alpha | 0.92 | 0.69 | 0.28 | CaM-KIIalpha | 0.94 | 0.65 | 0.37 | PDGFR | 0.94 | 0.70 | 0.45 |
Syk | 0.94 | 0.86 | 0.54 | GSK-3beta | 0.90 | 0.32 | 0.12 | CK1 | 0.93 | 0.55 | 0.23 |
Fyn | 0.90 | 0.25 | 0.13 | CaM-KII_group | 0.92 | 0.62 | 0.20 | CDK5 | 0.97 | 0.87 | 0.75 |
MAPK_group | 0.92 | 0.64 | 0.54 | PKB_group | 0.94 | 0.93 | 0.41 | PAK1 | 0.94 | 0.50 | 0.25 |
The mean accuracy, precision, and recall of the new method for 48 kinases are 0.93, 0.59, and 0.43, respectively.