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The computational framework of the proposed approach F_HapMiner. (1) Infer haplotypes on all families based on the DSS algorithm. (2) Calculate the phenotype score for each founder haplotype from each family based on its occurrences in affected and normal members. (3) Cluster all the founder haplotypes using a position weighted haplotype similarity measure. (4) Evaluate the correlation between clusters and the trait using a statistical test.
