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Synthesis of IZD inhibitor 2. Reagents and conditions: (a) Pd(OAc)2, KF, CyJohnPhos, THF, 50 °C; (b) Tf2O, Et3N, CH2Cl2, -78 °C; (c) Pd2(dba)3·CHCl3, K3PO4, SPhos, B2pin2, toluene, 100 °C; (d) Pd(OAc)2, K3PO4, SPhos, cat. H2O, THF, 60 °C; (e) NaBH4, MeOH, 0 °C; (f) m-CPBA, CH2Cl2, 0 °C to rt; (g) d-TFA, H2O, 80 °C.
