Figure 3. RA Th17 cells use Itgβ7 to migrate to the whole intestine including the lamina propria and gut-associated lymphoid tissues.
(A) Expression of CCR9 and α4β7 by wild type and Itgβ7 (−/−) RA Th17 cells. (B) The Th17 cells were injected i.v. and the migration of Th17 cells to the indicated organs were determined 20 h post cell-injection. (C) The localization of the injected Th17 cells in the indicated tissues was determined with a confocal microscope. The experiments were performed 3 times, and combined data (B) or representative data (C) are shown. *Significant changes.