Table 1. Characteristics of animal cohort.
| Animal ID | Mamu type* | Immunotherapy¶ | Set point virus load (RNA copies/mL)† | Time of sacrifice (weeks PI) ‡ | Disease status at sacrifice |
| Stable | |||||
| R478 | A-02/A-08/B-01 | Control | 3,376,666 | 56 | Healthy |
| R479 | A-01 | Ad-SIV | 410,333 | 62 | Healthy |
| R480 | A-01 | Control | 796,666 | 56 | Healthy |
| R481 | ND | Ad-SIV/IL-15 | 189,333 | 63 | Healthy |
| R484 | A-11 | Control | 2,396,666 | 62 | Healthy |
| R486 | ND | Ad-SIV | 121,666 | 62 | Healthy |
| R487 | A-01/B-01 | Ad-SIV/IL-15 | 5,833,333 | 61 | Healthy |
| R489 | A-08/B-17 | Ad-SIV | 1,316,666 | 62 | Healthy |
| M5306 | ND | Control | 99,000 | 63 | Healthy |
| M5506 | A-08 | Ad-SIV/IL-15 | 3,126,666 | 56 | Healthy |
| M5606 | A-08 | Ad-SIV/IL-15 | 7,300,000 | 60 | Healthy |
| Mean | 2,269,727 | 60 | |||
| Progressor | |||||
| R180 | B-01 | Ad-SIV | 671,000 | 43 | AIDS |
| R183 | B-17 | Ad-SIV/IL-15 | 706,666 | 43 | AIDS |
| R189 | A-02 | None | 47,500,000 | 11 | AIDS |
| R477 | ND | Ad-SIV | 14,300,000 | 32 | AIDS |
| R482 | B-01 | Control | 12,733,333 | 27 | AIDS |
| R483 | ND | Ad-SIV | 6,700,000 | 40 | AIDS |
| R485 | ND | Ad-SIV/IL-15 | 1,870,000 | 33 | AIDS |
| R488 | B-01 | Ad-SIV/IL-15 | 82,000,000 | 18 | AIDS |
| M5206 | A-02 | Ad-SIV | 11,333,333 | 36 | AIDS |
| M5406 | ND | Control | 15,700,000 | 42 | AIDS |
| Mean | 19,351,433 | 32 | |||
| P | 0.01 | <0.0001 |
*Expression of known MHC class I Mamu alleles. ND = none of the 8 alleles tested was expressed.
¶: Immunotherapy was administered at weeks 16 and 22 for Ad5-based vectors and weeks 36 and 42 for Ad35-based vectors. Control = Ad-ψ5; Ad-SIV = separate vectors expressing SIV Env, Gag and Nef; Ad-SIV/IL-15 = separate vectors expressing SIV Env, Gag, Nef and IL-15.
†: Mean values from week 8–12 post infection.
‡: Animals in the stable group were electively sacrificed at or after 56 weeks post infection (PI). Animals in the progressor group were sacrificed due to development of AIDS at the indicated times.