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. 2010 Dec 23;6(12):e1001249. doi: 10.1371/journal.ppat.1001249

Figure 7. Molecular architecture of co-receptor-binding site antibody (7D3) complexes on SIV CP-MAC Env and fitted gp120 coordinates.

Figure 7

(a, b) Perspective (a) and top (b) views of 7D3-bound SIV CP-MAC Env rendered as isosurfaces. (c, d) Fit of gp120 coordinates shown as isosurfaces to the density maps (green mesh) for 7D3-bound SIV CP-MAC Env rendering from perspective (c) and top views (d). The coordinates for 17b Fab were utilized for representing 7D3 (shown in red ribbons) and fit into the difference density calculated between the antibody-bound and corresponding unliganded SIV CP-MAC Env maps. Residues in the CD4 binding site and in the stem of the V1/V2 and V3 loops are shown in yellow, red and green, respectively, with proposed coreceptor-binding site (CoRbs) residues [34] shown in magenta.