Figure 8. The effects of the familial sick sinus syndrome (SSS) Na+ channel mutation P1298L in the mosaic model.

Figure 8A and B: Simulations after incorporation of the P1298L sodium mutation with and without vagal stimulation in the mosaic model are shown. The left panels of A and B show the effect of the mutation on interspersed atrial cells within the SAN alone. The right panels show the effect when the mutation is also incorporated into atrial cells.