Table 2.
Development of X4 variants causing tropism switch
| Patient | Variant | Fraction of population at | ||
|---|---|---|---|---|
| time 1 | time 2 | time 3 | ||
| 07 | CTRPGNNTRRSIRIGPGQTFFAREDIIGDIRQAYC | 0.01 | 0.07 | 0.73 |
| 18 | CERPNNNTRQRLSIGPGRSFYTSRRIIGDVKKAHC | 0.005 | 0.79 | 0.71 |
| 19 | CTRPNNNTRKGIYLGPGRAFYTTDKIIGDIRQAHC | 0.007 | 0.43 | 0.08 |
| 47 | CTRPNNSTRKSINIGPGSAWYTTGDIIGDIRQAHC | 0.0009 | 0.0 | 0.0 |
Development of the X4 seed strains in Subjects 07, 18, 19 with tropism switches and the largest initial X4 strain in patient 47 who does not show a tropism switch. The three times are the sampling points along the "Time" axis in Figure 1.